A human oil change. Explained.
EBOO — Extracorporeal Blood Oxygenation and Ozonation — is a one-hour medical procedure that filters your blood through a dialysis-grade membrane and re-oxygenates it with medical-grade ozone before returning it to your circulation. This is the long explanation. The short one is on the homepage.
A medical-grade blood filtration circuit, run for an hour.
EBOO is performed using a closed-loop circuit. A small IV draws blood from a vein in one arm, runs it through a sealed dialysis-grade membrane while simultaneously infusing it with medical ozone, and returns the cleaned, oxygenated blood through a second IV in the other arm. The blood never touches outside air. The filter, tubing, and ozonator are sterile, single-patient, and disposed of after each session.
One to two litres of your blood pass through the circuit during a typical session. That's roughly a third of your total volume cycled through filtration and ozonation in one sitting — which is why a single EBOO session is often described as the equivalent of dozens of standard ozone autohaemotherapy treatments.
It's not new science. Extracorporeal ozonation has been used clinically since the 1980s, predominantly in European integrative medicine. What's new is the equipment: modern membrane materials, precision-controlled ozone concentrations, and reliable flow rates have made the procedure faster, safer, and more reproducible than the early autohaemotherapy techniques it evolved from.
Four stages, one continuous loop.
- — 01
Blood is drawn.
A single IV in your left arm. Flow rate is gentle — about 1.5 litres per hour — so you'll feel almost nothing. Most clients read, work, or simply rest during the session.
- — 02
It passes through a filter.
A medical-grade dialysis membrane (typically 0.2 micron) catches the residue your body has been carrying: inflammatory proteins, oxidised lipids, AGEs (advanced glycation end-products), heavy metal complexes, and microplastic particles. The membrane is single-use and sealed.
- — 03
It is ozonated.
Medical ozone (O₃) is dissolved into the filtered blood at a precisely calibrated dose — usually 40 micrograms per millilitre, within the established therapeutic window. Ozone is a strong but short-lived oxidiser; it reacts immediately with lipids and proteins, generating signalling molecules that activate the body's own antioxidant defence system.
- — 04
It returns, oxygenated.
Through a second IV in your right arm. The blood that re-enters circulation carries more dissolved oxygen, fewer accumulated metabolites, and a freshly activated NRF2 / Keap1 signalling cascade that propagates the anti-inflammatory effect for days afterwards.
Three measurable biological shifts.
EBOO's therapeutic effect isn't one mechanism — it's a sequence. The same hour-long procedure triggers three different responses, each on its own timeline.
- — 01
NRF2 activation
Ozone's controlled oxidative stress signals the cell's master antioxidant transcription factor (NRF2) to activate. NRF2 upregulates dozens of cytoprotective enzymes — glutathione synthesis, heme oxygenase-1, catalase. The effect peaks 24–72 hours after the session.
- — 02
Reduced inflammatory load
The dialysis stage physically removes circulating inflammatory mediators and oxidised lipids. Measured CRP (C-reactive protein) typically drops modestly after a session; the larger effect comes from the cumulative course your doctor designs for you.
- — 03
Improved oxygen delivery
Re-oxygenated blood briefly raises plasma oxygen saturation and shifts the oxygen-haemoglobin dissociation curve. The mitochondrial effect — improved ATP generation per oxygen molecule — accounts for the energy and clarity many clients report within hours.
For the full mechanism breakdown, citations, and the assessment methodology, see the science page.
What we see, in practice.
EBOO doesn't treat conditions in the way a pharmaceutical does. It restores the body's underlying antioxidant capacity and lowers inflammatory burden — which means it shifts the substrate that many chronic conditions sit on top of. The clinical evidence base is uneven (this is well-trodden in some areas, exploratory in others) but the practical pattern of who responds is consistent.
- Strong response
- ·Chronic fatigue syndrome / ME-CFS
- ·Fibromyalgia
- ·Post-viral fatigue (Long COVID / PASC)
- ·Recurrent infections and immune dysregulation
- Supportive role
- ·Autoimmune flare management (RA, Hashimoto's, MS)
- ·Lyme disease and co-infections
- ·Chronic inflammatory states
- ·Pre- and post-surgical recovery
- Performance & longevity
- ·Elite training recovery and oxidative stress reset
- ·Cognitive performance and focus optimisation
- ·Anti-aging protocols (with NAD+, peptides, HBOT)
- ·Pre-conditioning before high-stakes events
- Investigational
- ·Cardiovascular plaque burden
- ·Mould and biotoxin illness
- ·Heavy metal load (with chelation)
- ·Skin inflammation and dermatological conditions
Note: HSW makes no claim that EBOO cures or treats any condition. EBOO is offered as a wellness procedure that supports the body's own restorative capacity. Whether it is appropriate for any individual is a clinical decision made by your consulting physician.
From walk-in to walk-out.
- 10 min
Arrival and intake
Brief health questionnaire if it's your first session, blood pressure, and a quick wellbeing check.
- 5 min
IV access
A nurse places two small IV cannulas — one in each arm. Standard hospital-grade kit.
- 60 min
The session itself
Blood cycles through the EBOO machine for around an hour. You sit in a private treatment room with a recliner, a screen, Wi-Fi, and refreshments. Most clients read or work.
- 10 min
Recovery and exit
Cannulas removed, brief observation, and you're free to go. No driving restriction. Most return to their day immediately.
- 1–7 days
What you'll notice
Energy and clarity often shift within hours. The fuller anti-inflammatory effect builds over the following 3–7 days as NRF2-driven enzyme expression peaks.
What we screen for.
The procedure itself has a strong safety record when performed by trained physicians using sterile single-use equipment. The risk profile is comparable to a standard dialysis or blood-donation procedure — primarily limited to IV access and the venous return.
That said, three contraindications are non-negotiable. We screen for them in the assessment and again at the consultation:
G6PD deficiency / favism
A genetic condition in which red blood cells lack adequate glutathione regeneration. Standard contraindication to all ozone therapies. Often undiagnosed — we ask explicitly and refer for testing when there's a family history.
Pregnancy and trying to conceive
EBOO hasn't been demonstrated unsafe in pregnancy, but it hasn't been adequately studied for safety either. Standard precaution: no treatment during pregnancy or active TTC cycles.
Anticoagulant therapy and bleeding disorders
Active anticoagulation or known bleeding disorders need physician review before treatment. This isn't an automatic exclusion — it usually means an adjusted protocol or a delay until medication is reviewed.
Questions we get most often.
- Does it hurt?
- Two IV cannulas — a quick pinch each. During the session itself the blood draw is gentle and most clients describe it as 'nothing'.
- How long until I notice something?
- Most clients report a shift in energy or clarity within a few hours. The fuller anti-inflammatory effect builds over the following week as your antioxidant gene expression peaks.
- How many sessions do I need?
- That's specifically what the consultation is for. Number of sessions, cadence, and any adjunct interventions are determined by the doctor after reviewing your full picture — not by an algorithm or a generic protocol.
- Is it safe?
- Yes for the vast majority of healthy adults. We screen explicitly for the three medical contraindications and re-verify them at the consultation before any treatment is scheduled.
- Is EBOO regulated in the UK?
- EBOO is a complementary medicine procedure performed by GMC-registered doctors in CQC-regulated clinics. It is not currently a NICE-approved NHS treatment.
- How much does it cost?
- Individual sessions and protocol packages — pricing is discussed during your free consultation so we can give you the right protocol for your situation, not a generic quote.
- Where are you?
- Two locations. London: London Medical Rooms, Ground Floor, 1–5 Portpool Lane, Chancery Lane, London EC1N 7UU (020 4628 3137). Glasgow: 5th Floor, Ingram House, 227 Ingram Street, Glasgow G1 1DA (0141 488 8985).